Top Suppliers:I want be here
Related CAS#:
207556-07-8 36913-39-0
7439-87-4 85644-14-0
41251-37-0 865-50-9
1560-56-1 282107-30-6
32317-85-4 20710-47-8
1158522-08-7 940364-43-2
2416864-13-4 134104-43-1
131615-57-1 6906-52-1
2408969-39-9 2137661-56-2
930439-75-1 1018584-77-4

207556-07-8

207556-07-8 structure
207556-07-8 structure
  • Name: MPP+-d3(iodide)
  • Chemical Name: 4-phenyl-1-(trideuteriomethyl)pyridin-1-ium,iodide
  • CAS Number: 207556-07-8
  • Molecular Formula: C12H9D3IN
  • Molecular Weight: 300.15
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-12-26 07:11:33
  • Modify Date: 2024-01-06 12:17:30
  • MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Name 4-phenyl-1-(trideuteriomethyl)pyridin-1-ium,iodide
Synonyms N-Methyl-d3-4-phenylpyridinium iodide
MPP+-d3 Iodide
MFCD00134220
Description MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.

[3]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45.

[4]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.
Melting Point 168-169ºC(lit.)
Molecular Formula C12H9D3IN
Molecular Weight 300.15
Exact Mass 300.02000
PSA 3.88000
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311 + H331-H315-H319-H335
Precautionary Statements P261-P280-P301 + P310-P305 + P351 + P338-P311
RIDADR UN 2811 6.1/PG 2

Chemsrc provides CAS#:207556-07-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 207556-07-8 | Chemsrc address: https://www.chemsrc.com/en/baike/1120320.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved