36913-39-0

36913-39-0 structure

Name: MPP+ iodide
Chemical Name: 1-Methyl-4-phenylpyridinium iodide
CAS Number: 36913-39-0
Molecular Formula: C₁₁H₁₀IN
Molecular Weight: 283.10800
Catalog: Research Areas Neurological Disease
Create Date: 2016-06-04 05:58:58
Modify Date: 2024-01-02 17:49:39
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

Name	1-Methyl-4-phenylpyridinium iodide
Synonyms	MFCD00055096

Description	MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells[1]. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1, 2, 3 mM Incubation Time: 24 hours Result: SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.
References	[1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [2]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45. [3]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.

Molecular Formula	C₁₁H₁₀IN
Molecular Weight	283.10800
Exact Mass	282.98600
PSA	12.89000
LogP	3.74680

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311 + H331-H315-H319-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	23/24/25-36/37/38
Safety Phrases	26-36-45
RIDADR	UN 2811 6.1/PG 2
RTECS	UU6580000
HS Code	2933399090

Precursor 0
DownStream 5
28289-54-5 939-23-1 2065-66-9 127382-80-3
127382-75-6

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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