1446418-48-9

1446418-48-9 structure

Name: Abacavir hydroxyacetate
Chemical Name: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl 2-hydroxyacetate
CAS Number: 1446418-48-9
Molecular Formula: C₁₆H₂₀N₆O₃
Molecular Weight: 344.36800
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-01-18 13:43:17
Modify Date: 2024-01-02 20:07:05
Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2].

Name	[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl 2-hydroxyacetate
Synonyms	Abacavir hydroxyacetate Prurisol UNII-B3C7MG354B Acetic acid,2-hydroxy-,((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl ester

Description	Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice[2]. Animal Model: 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue[2] Dosage: 10 and 20 mg/kg Administration: Oral gavage; 10-20 mg/kg once Result: Decreased the concentration of PRINS and 1L-20, and reduced the lesion area of skin. Showed a better effect than methotrexate in controlling psoriasis.
References	[1]. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis - potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939. [2]. Menon, et al. CARBOCYCLIC NUCLEOSIDES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS. WO/2013/103601/Al.