99957-90-1
99957-90-1 structure
- Name: Org30958
- Chemical Name: (8S,9S,10S,13S,14S)-10-[(ethyldisulfanyl)methyl]-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
- CAS Number: 99957-90-1
- Molecular Formula: C21H30O2S2
- Molecular Weight: 378.59200
- Catalog: Research Areas Metabolic Disease
- Create Date: 2017-08-11 22:28:25
- Modify Date: 2024-01-17 17:49:38
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Org30958 is a potent aromatase inhibitor in vivo.
| Name | (8S,9S,10S,13S,14S)-10-[(ethyldisulfanyl)methyl]-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione |
|---|---|
| Synonyms | Org30958 |
| Description | Org30958 is a potent aromatase inhibitor in vivo. |
|---|---|
| Related Catalog | |
| Target |
Aromatase[1] |
| In Vivo | Besides inhibition of cornification of vaginal epithelium Org30958 (ORG 30958) decreases ovarian aromatase and plasma E2 levels in DHEAS-treated hypophysectomized rats. Plasma estradiol levels are also lowered by Org30958 in dogs which are treated with pregnant mare serum gonadotrophin in order to induce pro-estrus. Org30958 displays much less than 1/400th of the androgenic activity of testosterone propionate in immature castrated rats and appears to be devoid of estrogenic and anti-estrogenic activity in ovariectomized mature rats. A twice daily dose of 1.5 mg Org30958/kg postpones ovulation in mature female rats[1]. |
| References |
| Density | 1.19g/cm3 |
|---|---|
| Boiling Point | 532.1ºC at 760 mmHg |
| Molecular Formula | C21H30O2S2 |
| Molecular Weight | 378.59200 |
| Flash Point | 220.9ºC |
| Exact Mass | 378.16900 |
| PSA | 84.74000 |
| LogP | 5.46880 |
| Index of Refraction | 1.592 |
| Hazard Codes | Xi |
|---|