13419-46-0

13419-46-0 structure

Name: DCVC
Chemical Name: 2-amino-3-[(E)-1,2-dichloroethenyl]sulfanylpropanoic acid
CAS Number: 13419-46-0
Molecular Formula: C₅H₇Cl₂NO₂S
Molecular Weight: 216.08600
Catalog: Signaling Pathways Apoptosis TNF Receptor
Create Date: 2017-06-25 23:11:36
Modify Date: 2024-01-14 15:24:35
DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.

Name	2-amino-3-[(E)-1,2-dichloroethenyl]sulfanylpropanoic acid
Synonyms	DCVC S-((E)-1,2-Dichlor-vinyl)-L-cystein S-((E)-1,2-dichloro-vinyl)-L-cysteine (E)-S-(1,2-Dichloroethenyl)-L-cysteine L-Cysteine,S-(1,2-dichloroethenyl)-,(E)-(9CI) ALANINE,3-((1,2-DICHLOROVINYL)THIO)-,(E)-L L-Cysteine,S-((1E)-1,2-dichloroethenyl) L-Cysteine,S-(1,2-dichloroethenyl)-,(E) S-(1,2-dichlorovinyl)-L-cysteine S-(trans-1,2-Dichlorovinyl)-L-cysteine S-(1,2-Dichlorovinyl)cysteine

Description	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.
Related Catalog	Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Infection
References	[1]. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. [2]. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. [3]. Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49.

HS Code	2930909090

52-90-4

79-01-6

13419-46-0

Literature: McKinney et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 909,913

Precursor 2
52-90-4 79-01-6
DownStream 0

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%