866363-70-4

866363-70-4 structure
866363-70-4 structure
  • Name: N3-C5-NHS ester
  • Chemical Name: (2,5-dioxopyrrolidin-1-yl) 6-azidohexanoate
  • CAS Number: 866363-70-4
  • Molecular Formula: C10H14N4O4
  • Molecular Weight: 254.24300
  • Catalog: Research Areas Cancer
  • Create Date: 2017-11-12 01:55:55
  • Modify Date: 2024-01-13 19:32:51
  • N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Name (2,5-dioxopyrrolidin-1-yl) 6-azidohexanoate
Synonyms 6-azidohexanoic acid N-hydroxysuccinimide ester
6-azidohexanoic acid succinimidyl ester
2,5-dioxopyrrolidin-1-yl 6-azidohexanoate
2,5-Pyrrolidinedione,1-[(6-azido-1-oxohexyl)oxy]
N-(6-azidohexanoyl)succinimide
succinimidyl 6-azidohexanoate
Description N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

Noncleavable

References

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

Molecular Formula C10H14N4O4
Molecular Weight 254.24300
Exact Mass 254.10200
PSA 113.43000
LogP 0.85496
Precursor  3

DownStream  0