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57-67-0

57-67-0 structure
57-67-0 structure

Name Sulfaguanidine
Synonyms Suganyl
Ruocid
Ganidan
Sulgin
sulfanilylguanidine
A-307
sulphaguanidine
Diacta
MFCD00038136
Sulfaguanidin
rp2275
4-aminobenzene-sulfonyl-guanidine
EINECS 200-345-9
Aterian
Description Sulfaguanidine is a sulfonamide, used as an antibiotic.
Related Catalog
Density 1.6±0.1 g/cm3
Boiling Point 426.1±47.0 °C at 760 mmHg
Melting Point 190-193°C
Molecular Formula C7H10N4O2S
Molecular Weight 214.245
Flash Point 211.5±29.3 °C
Exact Mass 214.052444
PSA 130.44000
LogP -1.22
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.695
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 1g/1000mL at 25 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WO8575000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-amidino-
CAS REGISTRY NUMBER :
57-67-0
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C7-H10-N4-O2-S
MOLECULAR WEIGHT :
214.27
WISWESSER LINE NOTATION :
ZR DSWMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 31(3),11,1966
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX. Volume(issue)/page/year: 67,163,1940 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22500 mg/kg
SEX/DURATION :
female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - abortion
REFERENCE :
AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 7,180,1950
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22500 mg/kg
SEX/DURATION :
female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 7,180,1950
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5880 mg/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 81,259,1987 *** REVIEWS *** TOXICOLOGY REVIEW JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ. Volume(issue)/page/year: 10,343,1943 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82004 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 700 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82004 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 16 No. of Employees: 1418 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR 3249
WGK Germany 3
RTECS WO8575000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2935009090

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Literature: Nature (London, United Kingdom), , vol. 148, p. 24 Biochemical Journal, , vol. 32, p. 1101,1109 CH229792 , ;

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Literature: Journal of Organic Chemistry, , vol. 21, p. 1198

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Literature: Journal of the Chemical Society, , p. 491,494
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%