316146-57-3

316146-57-3 structure

Name: ICA-105574
Chemical Name: 3-nitro-N-(4-phenoxyphenyl)benzamide
CAS Number: 316146-57-3
Molecular Formula: C₁₉H₁₄N₂O₄
Molecular Weight: 334.33
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-06-25 19:22:21
Modify Date: 2024-01-10 17:35:25
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].

Name	3-nitro-N-(4-phenoxyphenyl)benzamide
Synonyms	3-nitro-N-(4-phenoxyphenyl)-benzamide 3-NITRO-N-(4-PHENOXYPHENYL)BENZAMIDE F1107-0308

Description	ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010;77(1):58-68.