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58306-30-2

58306-30-2 structure
58306-30-2 structure
  • Name: Febantel
  • Chemical Name: Febantel
  • CAS Number: 58306-30-2
  • Molecular Formula: C20H22N4O6S
  • Molecular Weight: 446.477
  • Catalog: API Antiparasitic drug Anthelmintic
  • Create Date: 2018-08-22 10:06:16
  • Modify Date: 2024-01-03 17:16:41
  • Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.
Name Febantel
Synonyms {(Z)-({2-[(Méthoxyacétyl)amino]-4-(phénylsulfanyl)phényl}amino)[(méthoxycarbonyl)amino]méthylène}carbamate de méthyle
Dimethyl [[2-(2-Methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]dicarbamate
Carbamic acid, N,N'-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-, dimethyl ester
Dimethyl [({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)methylylidene]biscarbamate
Methyl-[N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamat
Bay h 5757
FEBANTEL PESTANAL
Febantel
Methyl {(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylene}carbamate
rintal
methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate (non-preferred name)
EINECS 261-205-0
[[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic Acid Dimethyl Ester
Methyl-{(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylen}carbamat
Bay h-5757
MFCD01738527
bayvh5757
Methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate
2-Acetamido-5-nitrothiazole VETRANAL
Description Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.
Related Catalog
Density 1.3±0.1 g/cm3
Melting Point 129-130ºC
Molecular Formula C20H22N4O6S
Molecular Weight 446.477
Exact Mass 446.126007
PSA 152.65000
LogP 2.36
Index of Refraction 1.598

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB3955000
CHEMICAL NAME :
Carbamic acid, ((2-((methoxyacetyl)amino)-4-(phenylthio)phenyl)carbo nimidoyl)bis-, dimethyl ester
CAS REGISTRY NUMBER :
58306-30-2
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H22-N4-O6-S
MOLECULAR WEIGHT :
446.52
WISWESSER LINE NOTATION :
1OVNUYMVO1&MR DSR& BMV1O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10605 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
RTECS FB3955000
34840-23-8 structure

34840-23-8

58306-67-5 structure

58306-67-5

~%

58306-30-2 structure

58306-30-2

Literature: FR2270861DE2423679 , ; Chem.Abstr., , vol. 84, # 73949
Precursor  2

DownStream  0


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