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31298-54-1

31298-54-1 structure
31298-54-1 structure
  • Name: Panepoxydone
  • Chemical Name: (1S,2R,6S)-2-hydroxy-4-(1-hydroxy-3-methylbut-2-enyl)-7-oxabicyclo[4.1.0]hept-3-en-5-one
  • CAS Number: 31298-54-1
  • Molecular Formula: C11H14O4
  • Molecular Weight: 210.22600
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2017-11-28 06:40:26
  • Modify Date: 2024-01-10 19:32:23
  • Panepoxydone is an inhibitor of NF-κB activation. Panepoxydone interferes with the NF-κB mediated signal transduction by inhibiting the phosphorylation of IκB. Panepoxydone exhibits antitumor, anti-inflammatory, antimalarial and anti-parasitic activity[1][2].

Name (1S,2R,6S)-2-hydroxy-4-(1-hydroxy-3-methylbut-2-enyl)-7-oxabicyclo[4.1.0]hept-3-en-5-one
Synonyms SL-3042
(1s,5r,6s)-5-hydroxy-3-(1-hydroxy-3-methylbut-2-en-1-yl)-7-oxabicyclo[4.1.0]hept-3-en-2-one
Antibiotic SL-3042
Panepoxydone
Description Panepoxydone is an inhibitor of NF-κB activation. Panepoxydone interferes with the NF-κB mediated signal transduction by inhibiting the phosphorylation of IκB. Panepoxydone exhibits antitumor, anti-inflammatory, antimalarial and anti-parasitic activity[1][2].
Related Catalog
References

[1]. Arora R, et, al. Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One. 2014 Jun 4;9(6):e98370.

[2]. Erkel G, et, al. Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. Int Immunopharmacol. 2007 May;7(5):612-24.

Molecular Formula C11H14O4
Molecular Weight 210.22600
Exact Mass 210.08900
PSA 70.06000
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII