566-97-2

566-97-2 structure

Name: Zymostenol
Chemical Name: 5α-cholest-8-en-3β-ol
CAS Number: 566-97-2
Molecular Formula: C₂₇H₄₆O
Molecular Weight: 386.65400
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2017-07-17 08:12:56
Modify Date: 2024-01-10 19:31:13
Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].

Name	5α-cholest-8-en-3β-ol
Synonyms	5alpha-cholest-8-en-3beta-ol Zymostenol

Description	Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Cancer
Target	Human Endogenous Metabolite RORγ:1 μM (EC50)
In Vitro	Zymostenol (12-104 μM) 促进小鼠外胚层干细胞来源的少突胶质细胞祖细胞中髓鞘碱性蛋白阳性 (MBP+) 少突胶质细胞的形成[2]。 Zymostenol (20 μM，3 天) 将 MCF-7 细胞周期停滞在 G0-G1 期[3]。 Cell Cycle Analysis[2] Cell Line: MCF-7 cells Concentration: 20 µM Incubation Time: 3 days Result: Induced 67 ± 1% accumulation of cells in the G0-G1 phase of the cell cycle.
References	[1]. Hu X, et al. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11(2):141-7. [2]. Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560(7718):372-376. [3]. Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7(12):3707-18.