885434-70-8
885434-70-8 structure
- Name: HJC 0350
- Chemical Name: 2,4-dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole
- CAS Number: 885434-70-8
- Molecular Formula: C15H19NO2S
- Molecular Weight: 277.38200
- Catalog: Research Areas Cancer
- Create Date: 2018-12-28 22:30:51
- Modify Date: 2024-01-31 10:13:51
-
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM.
| Name | 2,4-dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole |
|---|---|
| Synonyms |
HJC0350
HJC-0350 |
| Description | HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.3 µM (EPAC2)[1] |
| In Vitro | HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1]. |
| References |
| Molecular Formula | C15H19NO2S |
|---|---|
| Molecular Weight | 277.38200 |
| Exact Mass | 277.11400 |
| PSA | 47.45000 |
| LogP | 4.34790 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|---|
| RIDADR | NONH for all modes of transport |