850715-59-2

850715-59-2 structure

Name: SAMT-247
Chemical Name: Ethanethioic acid, S-[2-[[(3-amino-3-oxopropyl)amino]carbonyl]phenyl] ester
CAS Number: 850715-59-2
Molecular Formula: C₁₂H₁₄N₂O₃S
Molecular Weight: 266.32
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2017-03-04 06:27:56
Modify Date: 2024-01-08 11:31:07
SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].

Name	Ethanethioic acid, S-[2-[[(3-amino-3-oxopropyl)amino]carbonyl]phenyl] ester

Description	SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1IIIB:0.6 μM (EC50)
In Vitro	SAMT-247 通过共价修饰 Gag 多聚蛋白[2]。 SAMT-247 在被 HIV-1IIIB 感染的 CEM-SS 细胞中显示出 EC50 为 0.6 μM 的抗病毒活性。SAMT-247 显示出较低的细胞毒性(TC50 > 100 μM)[2]。
In Vivo	含有 1% SAMT-247 的凝胶配方保护了六只恒河猴中的五只免受 CCR5(R5)-趋向性 SHIV 阴道感染[3]。
References	[1]. Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204(12):3315-3328. [2]. Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6(12):887-9. [3]. Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25(15):1833-41.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport