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  • BioBioPha
  • China
  • Product Name: Mimosine
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng


  • DC Chemicals Limited
  • China
  • Product Name: NSC 69188
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

500-44-7

500-44-7 structure
500-44-7 structure
  • Name: Mimosine
  • Chemical Name: l-mimosine
  • CAS Number: 500-44-7
  • Molecular Formula: C8H10N2O4
  • Molecular Weight: 198.18
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-06-06 23:14:32
  • Modify Date: 2024-01-02 16:47:32
  • Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

Name l-mimosine
Synonyms Mimosine
(S)-2-amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionic acid
EINECS 207-905-1
leucenine
(S)-2-Amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionsaeure
(s)-1(4h)-pyridinepropanoicaci
MimosineLeucenol
MFCD00075909
L-Mimosine from Koa hoale seeds
L-LEUCININE
L(-)-MIMOSINE
LEUCENOL
Description Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.
Related Catalog
In Vitro Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2]. Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2]. Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4]. Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4]. Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4].
In Vivo Mimosine (30, and 60 mg/kg) decreases sperm concentration[5]. Animal Model: ICR male mice (6-8 weeks)[5] Dosage: 15, 30, or 60 mg/kg Administration: Injected (i.p.) for 7 consecutive days Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
References

[1]. Keiko Murakami, et al. Generation of reactive oxygen species by hydroxypyridone compound/iron complexes. Redox Rep. 2020 Dec;25(1):59-63.

[2]. Michael D H Honda, et al. Mimosine facilitates metallic cation uptake by plants through formation of mimosine-cation complexes.Plant Mol Biol. 2020 Mar;102(4-5):431-445.

[3]. MaherHallakMSc, et al. Mimosine Induces Apoptosis through Metal Ion Chelation, Mitochondrial Activation and Reactive Oxygen Species Production in Human Leukemic Cells. Blood.2004, Nov 16, 104 (11): 4481.

[4]. K S Kulp, et al. Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells. Toxicol Appl Pharmacol. 1996 Aug;139(2):356-64.

[5]. Pipatpong Kanla, et al. Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice. Int. J. Morphol., 36(2):507-512, 2018.

Density 1.544g/cm3
Boiling Point 428.6ºC at 760mmHg
Melting Point 224-228 °C
Molecular Formula C8H10N2O4
Molecular Weight 198.18
Flash Point 213ºC
Exact Mass 198.06400
PSA 105.55000
Index of Refraction 1.645
Storage condition 2-8C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S22-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933399090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%