Name | l-mimosine |
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Synonyms |
Mimosine
(S)-2-amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionic acid EINECS 207-905-1 leucenine (S)-2-Amino-3-(3-hydroxy-4-oxo-4H-[1]pyridyl)-propionsaeure (s)-1(4h)-pyridinepropanoicaci MimosineLeucenol MFCD00075909 L-Mimosine from Koa hoale seeds L-LEUCININE L(-)-MIMOSINE LEUCENOL |
Description | Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation. |
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Related Catalog | |
In Vitro | Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2]. Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2]. Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4]. Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4]. Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4]. |
In Vivo | Mimosine (30, and 60 mg/kg) decreases sperm concentration[5]. Animal Model: ICR male mice (6-8 weeks)[5] Dosage: 15, 30, or 60 mg/kg Administration: Injected (i.p.) for 7 consecutive days Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg. |
References |
Density | 1.544g/cm3 |
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Boiling Point | 428.6ºC at 760mmHg |
Melting Point | 224-228 °C |
Molecular Formula | C8H10N2O4 |
Molecular Weight | 198.18 |
Flash Point | 213ºC |
Exact Mass | 198.06400 |
PSA | 105.55000 |
Index of Refraction | 1.645 |
Storage condition | 2-8C |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H312-H332 |
Precautionary Statements | P280 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn |
Risk Phrases | R20/21/22 |
Safety Phrases | S22-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2933399090 |
Precursor 4 | |
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DownStream 0 |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |