157254-60-9

157254-60-9 structure

Name: 1,4-PBIT DIHYDROBROMIDE
Chemical Name: 2-[4-(2-carbamimidoylsulfanylethyl)phenyl]ethyl carbamimidothioate,dihydrobromide
CAS Number: 157254-60-9
Molecular Formula: C₁₂H₂₀Br₂N₄S₂
Molecular Weight: 444.25
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-12-30 08:48:24
Modify Date: 2024-01-18 17:53:16
1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].

Name	2-[4-(2-carbamimidoylsulfanylethyl)phenyl]ethyl carbamimidothioate,dihydrobromide
Synonyms	1,4-Phenylenedi-2,1-ethanediyl dicarbamimidothioate dihydrobromide 1,4-PB-ITU dihydrobromide Carbamimidothioic acid, 1,4-phenylenedi-2,1-ethanediyl ester, hydrobromide (1:2) 1,4-Phenylenediethane-2,1-diyl dicarbamimidothioate dihydrobromide 1,4-PBIT dihydrobromide

Description	1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	iNOS:7.6 nM (Ki) eNOS:360 nM (Ki) nNOS:16 nM (Ki)
References	[1]. E P Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.

Safety Phrases	S22-S24/25