85679-70-5

85679-70-5 structure

Name: Osteocalcin (45-49) (human)
Chemical Name: 2-[[1-[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
CAS Number: 85679-70-5
Molecular Formula: C₃₀H₃₉N₅O₇
Molecular Weight: 581.66000
Catalog: Research Areas Cancer
Create Date: 2018-10-15 09:23:24
Modify Date: 2024-01-10 15:31:05
Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo[1].

Name	2-[[1-[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
Synonyms	OSTEOCALCIN,Fragment 45-49 Phe-Tyr-Gly-Pro-Val Osteocalcin Fragment 45-49 human FYGPV

Description	Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Bovine bone Gla protein (BGP) (1 nM-10 μM) exerts chemotactic activity of (0.1 and 1 μM) cultured human breast cancer cells (MDA-MB-231 cells), (1 nM-1 μM) human peripheral blood monocytes, and (1-10 μM) rat osteosarcoma cells with osteoblast-like characteristics[1].
References	[1]. Mundy GR, et al. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Calcif Tissue Int. 1983;35(2):164-8.

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