Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hexamethylene bisacetamide
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Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Hexamethylene bisacetamide
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Purity: 98.9%
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DC Chemicals Limited
China
Product Name: Hexamethylene bisacetamide
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N,N'-Hexamethylenebisacetamide
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Purity: 98.0%
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Contact: Ms Wang

3073-59-4

3073-59-4 structure

3073-59-4 structure

Name: Hexamethylene bisacetamide
Chemical Name: N-(6-acetamidohexyl)acetamide
CAS Number: 3073-59-4
Molecular Formula: C₁₀H₂₀N₂O₂
Molecular Weight: 200.28
Catalog: Chemical reagent Organic reagent Amide
Create Date: 2018-06-15 12:26:56
Modify Date: 2024-01-02 19:32:22
Hexamethylene bisacetamide is a tumor cell-differentiating agent[1].

Name	N-(6-acetamidohexyl)acetamide
Synonyms	N,N‘-Hexamethylenebisacetamide N,N'-hexamethylene bis(acetamide) Hexamethylenediacetamide N,N'-diacetyl-1,6-hexanediamine hmba N,N′-Diacetyl-1,6-diaminohexane diacetyldiaminohexane EINECS 211-363-1 hexamethylenebis(acetamide) N,N-Hexamethylenediacetamide N,N'-DIACETYL-1,6-DIAMINOHEXANE MFCD00008684

Description	Hexamethylene bisacetamide is a tumor cell-differentiating agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Reuben RC, et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6.

Density	0.974 g/cm3
Boiling Point	456.7ºC at 760 mmHg
Melting Point	128-129 °C(lit.)
Molecular Formula	C₁₀H₂₀N₂O₂
Molecular Weight	200.28
Flash Point	193.2ºC
Exact Mass	200.15200
PSA	58.20000
LogP	1.60080

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC2976200

CHEMICAL NAME :: Acetamide, N,N'-hexamethylenebis-

CAS REGISTRY NUMBER :: 3073-59-4

BEILSTEIN REFERENCE NO. :: 1775764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H20-N2-O2

MOLECULAR WEIGHT :: 200.32

WISWESSER LINE NOTATION :: 1VM6MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4270 mg/kg/10D-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - thrombocytopenia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R33:Danger of cumulative effects.
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AC2976200
HS Code	2924199090

Precursor 10
124-09-4 121-44-8 75-36-5 60-35-5
64-19-7 822-06-0 692-33-1 105-74-8
68293-74-3 108-24-7
DownStream 10
79-16-3 60-35-5 2463-29-8 127-19-5
10151-12-9 13093-05-5 3066-65-7 16644-57-8
6030-54-2 1206701-19-0

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%