89197-00-2

89197-00-2 structure

Name: Efaroxan hydrochloride
Chemical Name: 2-(2-ethyl-3H-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole,hydrochloride
CAS Number: 89197-00-2
Molecular Formula: C₁₃H₁₇ClN₂O
Molecular Weight: 252.740
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-09-07 13:41:34
Modify Date: 2024-01-02 11:57:21
Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease[1][2][3].

Name	2-(2-ethyl-3H-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole,hydrochloride
Synonyms	Calmidazolium chloride (±)-efaroxan hydrochloride 2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride (1:1) Efaroxan HCl 1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-, hydrochloride (1:1) Efaroxan hydrochloride

Description	Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	α2-adrenoceptor, I1-Imidazoline receptor[1][2]
In Vitro	Efaroxan hydrochloride binds to I1-imidazoline and α2-adrenergic receptors in bovine rostral ventrolateral medulla membranes, with Kis of 0.15 and 5.6 nM, respectively[1]
In Vivo	Efaroxan hydrochloride increases plasma insulin levels in both conscious fed[3]. Animal Model: Male Sprague-Dawley rats (weight range 250-300g)[3] Dosage: 1 mg/kg, 5 mg/kg Administration: Oral administration Result: Significant increase in plasma insulin levels of starved rats 15 and 30 min after treatment.
References	[1]. T L Berridge, et al. Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat. Eur J Pharmacol. 1992 Mar 24;213(2):205-12. [2]. A O Abdel-Zaher, et al. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res. 2001 Nov;44(5):397-409. [3]. T L Berridge, et al. Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats. Eur J Pharmacol. 1992 Mar 24;213(2):213-8.

Boiling Point	387ºC at 760 mmHg
Molecular Formula	C₁₃H₁₇ClN₂O
Molecular Weight	252.740
Flash Point	187.9ºC
Exact Mass	252.102936
PSA	33.62000
LogP	2.33840

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	7-35-45
RIDADR	UN 2811 6.1/PG 3
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

89197-00-2	7013-41-4
70052-12-9	6138-79-0
143851-98-3	127228-87-9
1406-14-0	929-73-7
186694-02-0	65546-09-0
1158522-08-7	2138058-77-0
940364-43-2	2172583-68-3
134104-43-1	131615-57-1
2228689-39-0	6906-52-1
930439-75-1	1018584-77-4