745046-84-8

745046-84-8 structure

Name: Ivachtin
Chemical Name: 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
CAS Number: 745046-84-8
Molecular Formula: C₂₀H₂₁N₃O₇S
Molecular Weight: 447.462
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-12-22 06:35:16
Modify Date: 2024-01-10 13:10:53
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].

Name	2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
Synonyms	2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)- IVACHTIN Caspase-3 Inhibitor VII HMS3269H15 2-[4-Methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate

Description	Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Neurological Disease
Target	Caspase-3:23 nM (IC50)
In Vitro	Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells[1].
References	[1]. Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3.