102805-45-8

102805-45-8 structure

Name: (p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt
Chemical Name: L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide
CAS Number: 102805-45-8
Molecular Formula: C₁₄₈H₂₃₉ClN₄₄O₄₂
Molecular Weight: 3342.204
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-11-18 14:31:55
Modify Date: 2024-02-02 10:32:14
[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].

Name	L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide
Synonyms	L-Aspartamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutam inyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl- L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L -alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide 6-(4-Chloro-D-Phenylalanine)-17-L-Leucine-Vasoactive Intestinaloctacosapeptide (Swine) (p-Chloro-D-Phe6,Leu17)-VIP [4ClDPhe6,Leu17] VIP

Description	[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	IC50: 125.8 nM (VIP receptor)[1]
References	[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

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RIDADR	NONH for all modes of transport