102805-45-8

• 常用中文名：[D-p-Cl-Phe6,Leu17]-VIP
• 常用英文名：(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt
• CAS号：102805-45-8
• 分子式：C₁₄₈H₂₃₉ClN₄₄O₄₂
• 分子量：3342.204
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-11-18 14:31:55
• 更新时间：2024-02-02 10:32:14
• [D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂,IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素,促胰液素和 GRF 受体无活性。

名称

• 中文名: [D-p-Cl-Phe6, Leu17]-七磷酸庚糖血管活性肠肽,三氟乙酸盐
• 英文名: L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide
• 英文别名: L-Aspartamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutam inyl-L-leucyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-; L-Histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-4-chloro-D-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L -alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-aspartamide; 6-(4-Chloro-D-Phenylalanine)-17-L-Leucine-Vasoactive Intestinaloctacosapeptide (Swine); (p-Chloro-D-Phe6,Leu17)-VIP; [4ClDPhe6,Leu17] VIP

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₄₈H₂₃₉ClN₄₄O₄₂
• 分子量: 3342.204
• 精确质量: 3339.760742
• PSA: 1453.69000
• LogP: -4.01
• 折射率: 1.657
• 储存条件: -20°C

生物活性

• 描述: [D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂,IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素,促胰液素和 GRF 受体无活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点:

  IC50: 125.8 nM (VIP receptor)[1]

• 参考文献:

  [1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86.

  [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7.

  [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport