162641-16-9
162641-16-9 structure
- Name: HQL 79
- Chemical Name: 4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
- CAS Number: 162641-16-9
- Molecular Formula: C22H27N5O
- Molecular Weight: 377.48
- Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
- Create Date: 2018-12-18 11:53:59
- Modify Date: 2024-01-05 15:55:43
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HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].
| Name | 4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine |
|---|---|
| Synonyms |
4-(Diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine
HQL Piperidine, 4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]- cc-704 2cvd HQL-79 4-Benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]-piperidine |
| Description | HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6 μM (H-PGDS)[1] Kd: 0.8 μM (H-PGDS)[1] |
| In Vitro | HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.6±60.0 °C at 760 mmHg |
| Molecular Formula | C22H27N5O |
| Molecular Weight | 377.48 |
| Flash Point | 288.6±32.9 °C |
| Exact Mass | 377.221558 |
| PSA | 66.93000 |
| LogP | 3.94 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.619 |
| RIDADR | NONH for all modes of transport |
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