Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Src Inhibitor-1
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Purity: 98.0%
Stocking Period: 10 Day
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Src kinase inhibitor I
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
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DC Chemicals Limited
China
Product Name: Src kinase inhibitor I
Price: $450.0/100mg $800.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
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Purity: 98.0%
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Contact: Ms Wang

179248-59-0

179248-59-0 structure

179248-59-0 structure

Name: Src Inhibitor-1
Chemical Name: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
CAS Number: 179248-59-0
Molecular Formula: C₂₂H₁₉N₃O₃
Molecular Weight: 373.405
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2016-09-01 05:57:25
Modify Date: 2024-01-02 18:44:00
Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

Name	6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
Synonyms	6,7-Dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine Src Kinase Inhikitor Src Kinase Inhibitor I 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine Src-l1 4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)- Src Inhibitor-1 KIN001-030 Src Inhibitor 1

Description	Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer
Target	IC50: 44 nM (Src), 88 nM (Lck)[1]
In Vitro	Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2].
Kinase Assay	Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2].
References	[1]. Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochemistry. 2001 Jun 19;40(24):7084-91. [2]. Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.

Density	1.3±0.1 g/cm3
Boiling Point	528.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₉N₃O₃
Molecular Weight	373.405
Flash Point	273.2±30.1 °C
Exact Mass	373.142639
PSA	65.50000
LogP	4.90
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.665
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335-H413
Precautionary Statements	P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313
RIDADR	UN 3077 9 / PGIII