199655-36-2
199655-36-2 structure
- Name: CP465022 HCl
- Chemical Name: CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- CAS Number: 199655-36-2
- Molecular Formula: C26H24ClFN4O
- Molecular Weight: 462.95
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2016-03-21 12:14:23
- Modify Date: 2024-01-14 13:00:21
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CP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes[1][2].
| Name | CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride |
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| Synonyms | MFCD28160468 |
| Description | CP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes[1][2]. |
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| Related Catalog | |
| Target |
IC50: 25 nM (rat cortical neurons)[1] |
| In Vitro | CP-465022 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons[1]. CP-465022 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons[1]. CP-465022 (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%)[1]. |
| References |
| Molecular Formula | C26H24ClFN4O |
|---|---|
| Molecular Weight | 462.95 |
| Exact Mass | 498.13900 |
| PSA | 51.02000 |
| LogP | 6.38740 |
| Hazard Codes | Xi |
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