35619-65-9

35619-65-9 structure

Name: Tritiozine
Chemical Name: morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanethione
CAS Number: 35619-65-9
Molecular Formula: C₁₄H₁₉NO₄S
Molecular Weight: 297.37000
Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
Create Date: 2018-06-18 10:45:25
Modify Date: 2024-01-13 22:59:37
Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].

Name	morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanethione
Synonyms	EINECS 252-645-4 Tritiozine Tresanil Tritiozina [INN-Spanish] Tritiozina [Italian] ISF 2001 4-(3',4',5'-trimethoxyphenyl)-thioxomethylmorpholine Trithiozine 4-(3,4,5-Trimethoxythiobenzoyl)morpholine Tritiozinum [INN-Latin]

Description	Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vivo	Trithiozine (T) (i. p., oral, i. v.; 50 mg/kg, 200 mg/kg) shows a considerable antisecretory and antiulcer activity on different experimental models in the rats and dogs[1]. Animal Model: female Sprague-Dawley rats and male beagle dogs[1] Dosage: 50 mg/kg (rats); 200 mg/kg or 50 mg/kg (dogs) Administration: i. p., single (rats); oral, single or i. v. (dogs) Result: Showed an apparent plasma half-life of about 2.5 h in rats and 1 h in dogs and rapidly metabolized yielding two metabolites and two conjugates.
References	[1]. G. M. Pacifici, et al. Pharmacokinetics and biotransformation, in rats and dogs, of trithiozine, a new antisecretory drug. , 1(3), 141–147. doi:10.1007/bf03189268.