Name | Ivosidenib |
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Synonyms |
AG-120
2-Pyrrolidinecarboxamide, N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-, (2S)- ivosidenib N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide UNII:Q2PCN8MAM6 (2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide |
Description | Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H. |
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Related Catalog | |
Target |
12 nM (mouse IDH1R132H)[1] |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 854.3±65.0 °C at 760 mmHg |
Molecular Formula | C28H22ClF3N6O3 |
Molecular Weight | 582.961 |
Flash Point | 470.4±34.3 °C |
Exact Mass | 582.139404 |
LogP | 0.38 |
Vapour Pressure | 0.0±3.2 mmHg at 25°C |
Index of Refraction | 1.651 |
Storage condition | -20℃ |