878385-84-3

878385-84-3 structure

Name: AZD-5069
Chemical Name: azd-5069
CAS Number: 878385-84-3
Molecular Formula: C₁₈H₂₂F₂N₄O₅S₂
Molecular Weight: 476.518
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2016-12-02 21:14:12
Modify Date: 2024-01-02 11:44:02
AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.

Name	azd-5069
Synonyms	1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]- N-(2-[(2,3-Difluorobenzyl)sulfanyl]-6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-4-pyrimidinyl)-1-azetidinesulfonamide

Description	AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Cancer
Target	125I-IL-8-CXCR2
In Vitro	AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye[1].
References	[1]. Norman P. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.