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2149-70-4

2149-70-4 structure
2149-70-4 structure
  • Name: H-Arg(NO2)-OH
  • Chemical Name: N'-Nitro-L-arginine
  • CAS Number: 2149-70-4
  • Molecular Formula: C6H13N5O4
  • Molecular Weight: 219.199
  • Catalog: Biochemical Amino acids and their derivatives Arginine derivatives
  • Create Date: 2018-06-22 01:23:07
  • Modify Date: 2024-01-02 19:43:19
  • Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects. Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine. Nitroarginine is currently in clinical trials for treating patients with advanced solid tumors.

Name N'-Nitro-L-arginine
Synonyms (S)-2-Amino-5-(3-nitroguanidino)pentanoic acid
L-Ornithine, N-[(E)-imino(nitroamino)methyl]-
ARG(NO2)
L-NNA
N-ω-NITRO-L-ARGININE
L-NOARG
Nω-Nitro-L-arginine
(S)-2-Aminobut-3-enoic acid
H-Arg(NO2)-OH
L-Ornithine, N5-(imino(nitroamino)methyl)-
H-ARG(NO2)-OME
Nω-Nitro-L-arginine (L-NNA)
NG-nitro-L-arginine
EINECS 218-418-9
MFCD00007033
NG-NO2-L-ARG
L-NA,L-NNA
L-NA
L-NO2ARG
nitroarginine
Nomega-nitro-L-arginine
L-NNA N5-(Nitroamidino)-L-2,5-diaminopentanoic acid NG-NO2-L-Arg
L-NG-nitroarginine
N-(N-Nitrocarbamimidoyl)-L-ornithine
Density 1.7±0.1 g/cm3
Boiling Point 462.4±55.0 °C at 760 mmHg
Melting Point 257 °C (dec.)(lit.)
Molecular Formula C6H13N5O4
Molecular Weight 219.199
Flash Point 233.5±31.5 °C
Exact Mass 219.096756
PSA 157.05000
LogP -0.79
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.638
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3

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2149-70-4 structure

2149-70-4

Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 224, p. 40,43

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2149-70-4 structure

2149-70-4

Literature: Justus Liebigs Annalen der Chemie, , vol. 642, p. 145 - 162

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2149-70-4 structure

2149-70-4

Literature: Chemische Berichte, , vol. 97, p. 3312 - 3316 Bulletin of the Chemical Society of Japan, , vol. 38, p. 1148 - 1157

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2149-70-4 structure

2149-70-4

Literature: Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 72, p. 489