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1119-34-2

1119-34-2 structure
1119-34-2 structure
  • Name: L-Arginine hydrochloride
  • Chemical Name: 2-Amino-5-guanidinovaleric acid monohydrochloride
  • CAS Number: 1119-34-2
  • Molecular Formula: C6H15ClN4O2
  • Molecular Weight: 210.662
  • Catalog: Biochemical Common amino acids and protein drugs
  • Create Date: 2018-06-11 01:38:23
  • Modify Date: 2024-01-02 17:24:36
  • L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Name 2-Amino-5-guanidinovaleric acid monohydrochloride
Synonyms (+)-L-arginine hydrochloride
Arginine, hydrochloride, L-
(2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride
levargin
L-Arginine HCl
L-(+)-Arginine monohydrochloride
L-Arginine hydrochloride
L-ARG HCL
(S)-2-Amino-5-guanidinopentanoic acid hydrochloride
(S)-(+)-Arginine hydrochloride,L-Arginine hydrochloride
L-Arginine hydrochloride (1:1)
(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
2-Amino-5-guanidinovalericacidmonohydrochloride
anhydrous L-arginine monohydrochloride
L-Arginine HCl (L-Arg)
Arginine hydrochloride
L-Arginine.HCl
Arginine Muriate
S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
(S)-arginine hydrochloride
L(+)-Arginine hydrochloride
ARG,HCL
(2S)-2-Amino-5-carbamimidamidopentansäurehydrochlorid
L-Arginine, hydrochloride (1:1)
EINECS 214-275-1
L-Arginine Monohydrochloride (VAN)
2-Amino-5-guanidinovaleric ac
detoxargin
r-gene
Arginine HCL
argivene
MFCD00064550
H-Arg-OH.HCl
L-arginine, hydrochloride
acide (2S)-2-amino-5-carbamimidamidopentanoïque chlorhydrate
L-Arginine monohydrochloride
minophagena
L-Arginine (hydrochloride)
Description L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Related Catalog
References

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.

[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.
Density 1.42
Boiling Point 409.1ºC at 760 mmHg
Melting Point 226-230 °C(lit.)
Molecular Formula C6H15ClN4O2
Molecular Weight 210.662
Flash Point 201.2ºC
Exact Mass 210.088348
PSA 125.22000
LogP 1.35480

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CF1995500
CHEMICAL NAME :
Arginine, monohydrochloride, L-
CAS REGISTRY NUMBER :
1119-34-2
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C6-H14-N4-O2.Cl-H
MOLECULAR WEIGHT :
210.70
WISWESSER LINE NOTATION :
MUYZM3YZVQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3793 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
90 mg/kg
SEX/DURATION :
female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 51,553,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81859 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 857 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81859 No. of Facilities: 585 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 5477 (estimated) No. of Female Employees: 2954 (estimated)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CF1995500
HS Code 2922499990
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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