- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: N-Boc-serinol
- Price:
- Purity: 97.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: N-Boc-serinol
- Price: ￥116.0/1g ￥456.0/5g ￥756.0/10g ￥46.0/250mg
- Purity: 97.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: T-Butyl 1,3-dihydroxypropan-2-ylcarbamate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: TERT-BUTYL (1,3-DIHYDROXYPROPAN-2-YL)CARBAMATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
125414-41-7
125414-41-7 structure
- Name: N-Boc-serinol
- Chemical Name: tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate
- CAS Number: 125414-41-7
- Molecular Formula: C8H17NO4
- Molecular Weight: 191.225
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-03-16 08:00:00
- Modify Date: 2024-01-08 11:37:10
-
N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate |
|---|---|
| Synonyms |
tert-butyl N-(1,3-dihydroxypropan-2-yl)carbamate
2-Methyl-2-propanyl (1,3-dihydroxy-2-propanyl)carbamate Carbamic acid, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester 1,1-Dimethylethyl [2-hydroxy-1-(hydroxymethyl)ethyl]carbamate |
| Description | N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 363.0±32.0 °C at 760 mmHg |
| Melting Point | 85-89ºC |
| Molecular Formula | C8H17NO4 |
| Molecular Weight | 191.225 |
| Flash Point | 173.4±25.1 °C |
| Exact Mass | 191.115753 |
| PSA | 78.79000 |
| LogP | 0.30 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.476 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924199090 |
|
~48%
125414-41-7 |
| Literature: GE HEALTHCARE AS Patent: WO2009/60021 A1, 2009 ; Location in patent: Page/Page column 21-22 ; |
|
~98%
125414-41-7 |
| Literature: Upadhyaya, Dharita J.; Barge, Alessandro; Stefania, Rachele; Cravotto, Giancarlo Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8318 - 8322 |
|
~83%
125414-41-7 |
| Literature: Morales-Serna, Jose Antonio; Garcia-Rios, Erendira; Bernal, Jorge; Paleo, Ehecatl; Gavino, Ruben; Cardenas, Jorge Synthesis, 2011 , # 9 art. no. M12811SS, p. 1375 - 1382 |
| Precursor 4 | |
|---|---|
| DownStream 1 | |
![[2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-methylsulfonyloxypropyl] methanesulfonate structure](https://image.chemsrc.com/caspic/151/213475-70-8.png)
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |