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125414-41-7

125414-41-7 structure
125414-41-7 structure
  • Name: N-Boc-serinol
  • Chemical Name: tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate
  • CAS Number: 125414-41-7
  • Molecular Formula: C8H17NO4
  • Molecular Weight: 191.225
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-03-16 08:00:00
  • Modify Date: 2024-01-08 11:37:10
  • N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate
Synonyms tert-butyl N-(1,3-dihydroxypropan-2-yl)carbamate
2-Methyl-2-propanyl (1,3-dihydroxy-2-propanyl)carbamate
Carbamic acid, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester
1,1-Dimethylethyl [2-hydroxy-1-(hydroxymethyl)ethyl]carbamate
Description N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Density 1.1±0.1 g/cm3
Boiling Point 363.0±32.0 °C at 760 mmHg
Melting Point 85-89ºC
Molecular Formula C8H17NO4
Molecular Weight 191.225
Flash Point 173.4±25.1 °C
Exact Mass 191.115753
PSA 78.79000
LogP 0.30
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.476
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26
RIDADR NONH for all modes of transport
HS Code 2924199090
34619-03-9 structure

34619-03-9
534-03-2 structure

534-03-2

~48%

125414-41-7 structure

125414-41-7
Literature: GE HEALTHCARE AS Patent: WO2009/60021 A1, 2009 ; Location in patent: Page/Page column 21-22 ;
24424-99-5 structure

24424-99-5
534-03-2 structure

534-03-2

~98%

125414-41-7 structure

125414-41-7
Literature: Upadhyaya, Dharita J.; Barge, Alessandro; Stefania, Rachele; Cravotto, Giancarlo Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8318 - 8322
3262-72-4 structure

3262-72-4

~83%

125414-41-7 structure

125414-41-7
Literature: Morales-Serna, Jose Antonio; Garcia-Rios, Erendira; Bernal, Jorge; Paleo, Ehecatl; Gavino, Ruben; Cardenas, Jorge Synthesis, 2011 , # 9 art. no. M12811SS, p. 1375 - 1382
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Chemsrc provides CAS#:125414-41-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 125414-41-7 | Chemsrc address: https://www.chemsrc.com/en/baike/123604.html

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