85320-68-9
85320-68-9 structure
- Name: Amosulalol
- Chemical Name: 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
- CAS Number: 85320-68-9
- Molecular Formula: C18H24N2O5S
- Molecular Weight: 380.45900
- Catalog: API Circulatory system medication Beta-adrenergic receptor blocker
- Create Date: 2018-10-02 10:57:41
- Modify Date: 2024-01-06 17:01:10
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Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1].
| Name | 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide |
|---|---|
| Synonyms |
Amosulalolum [Latin]
5-[1-hydroxy-2-[2-(2-methoxyphenoxyl)ethylamino]ethyl]-2-methylbenzenesulfonamide (+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamide Amosulalolum Lowgan Amosulalol (+/-)-5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamide Amosulalol [INN] |
| Description | Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1]. |
|---|---|
| Related Catalog | |
| Target |
α1-adrenergic receptor Beta-1 adrenergic receptor |
| In Vivo | Amosulalol (3-30 mg/kg; 口服; 单剂量) 降低高血压大鼠的急性收缩压[1]。 Amosulalol (50 mg/kg; 口服; 每天 2 次, 共 12 周) 产生不耐受的降压作用，还降低高血压大鼠模型中心率和血浆肾素活性 (PRA) 增加[1]。 |
| References |
| Density | 1.268g/cm3 |
|---|---|
| Boiling Point | 608.7ºC at 760mmHg |
| Molecular Formula | C18H24N2O5S |
| Molecular Weight | 380.45900 |
| Flash Point | 321.9ºC |
| Exact Mass | 380.14100 |
| PSA | 119.26000 |
| LogP | 3.52500 |
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~%
85320-68-9 |
| Literature: Yamanouchi Pharm. Patent: DE2843016 , 1979 ; Chem.Abstr., 1979 , vol. 91, # 157445 |
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85320-68-9 |
| Literature: Yamanouchi Pharm. Patent: DE2843016 , 1979 ; Chem.Abstr., 1979 , vol. 91, # 157445 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |