60117-17-1

60117-17-1 structure

Name: [Met5]enkephalin amide
Chemical Name: [Met5]enkephalin amide
CAS Number: 60117-17-1
Molecular Formula: C₂₇H₃₆N₆O₆S
Molecular Weight: 572.67600
Catalog: Peptides
Create Date: 2018-03-02 05:48:05
Modify Date: 2024-01-02 17:19:40
[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

Name	[Met5]enkephalin amide
Synonyms	YGGFM-NH2 [Met-NH2]5-enkephalin (Met5)-enkephalinamide Met5-enkephallin amide methionine enkephalinamide Met-enkephalin amide [MET5]-ENKEPHALIN AMIDE

Description	[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Peptides Research Areas >> Neurological Disease
Target	δ and ζ opioid receptor[1]
In Vitro	[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
References	[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48. [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.