1273323-67-3
1273323-67-3 structure
- Name: YLF-466D
- Chemical Name: 3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]benzoic acid
- CAS Number: 1273323-67-3
- Molecular Formula: C29H20ClNO3
- Molecular Weight: 465.92700
- Catalog: Signaling Pathways Epigenetics AMPK
- Create Date: 2018-06-12 18:41:27
- Modify Date: 2024-01-08 18:15:57
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YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.
| Name | 3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]benzoic acid |
|---|---|
| Synonyms |
(E)-3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid
3-{3-[1-(4-chloro-phenyl)-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid 3-{3-[1-(4-chlorophenyl)-1-phenylmeth-(E)-ylidene]-2-oxo-2,3-dihydroindol-1-ylmethyl}-benzoic acid 3-((3-((4-chlorophenyl)(phenyl)meth-(E)-ylene)-2-oxoindolin-1-yl)methyl)benzoic acid YLF-466D |
| Description | YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation. |
|---|---|
| Related Catalog | |
| Target |
AMPK |
| In Vitro | The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively[1]. |
| Kinase Assay | Blood is collected from the abdominal aorta of ether anesthetized rats using 3.2% sodium citrate as an anticoagulant (sodium citrate:blood=1:9) and diluted with normal saline (1:1). Blood is incubated with YLF-466D (0, 50, 100 and 150 μM) for 3 min and aggregation is induced with 7.5 μg/mL Collagen. Aggregation is assessed by measuring the impedance change with a whole blood aggregometer[1]. |
| References |
| Molecular Formula | C29H20ClNO3 |
|---|---|
| Molecular Weight | 465.92700 |
| Exact Mass | 465.11300 |
| PSA | 57.61000 |
| LogP | 6.60910 |
| Storage condition | 2-8℃ |