140405-36-3

140405-36-3 structure

Name: RSVA 405
Chemical Name: N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide
CAS Number: 140405-36-3
Molecular Formula: C₁₇H₂₀N₄O₂
Molecular Weight: 312.36600
Create Date: 2018-05-14 01:53:58
Modify Date: 2024-04-09 18:37:11
RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.

Name	N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide
Synonyms	p-(N,N-diethylamino)salicylaldehyde isonicotinoylhydrazone N'-[4-(diethylamino)-2-hydroxybenzylidene]isonicotinohydrazide Hit2Lead 5113025 ST 91