107355-45-3

107355-45-3 structure

Name: WIN 54954
Chemical Name: 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
CAS Number: 107355-45-3
Molecular Formula: C₁₈H₂₀Cl₂N₂O₃
Molecular Weight: 383.27
Catalog: Research Areas Infection
Create Date: 2018-05-11 06:43:46
Modify Date: 2024-01-04 11:32:37
WIN 54954 is a broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections[1][2].

Name	5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
Synonyms	5-<5-(2,6-dichloro-5-oxazolylphenoxy)pentyl>-3-methylisoxazole 5-{5-[2,6-Dichloro-4-(4,5-dihydro-oxazol-2-yl)-phenoxy]-pentyl}-3-methyl-isoxazole 5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole WIN 54954 Win 54954 5-{5-[2,6-Dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxyl]-pentyl}-3-methylisoxazole

Description	WIN 54954 is a broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL)[1].WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/mL[1].
In Vivo	WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively[1].
References	[1]. Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74. [2]. Fechner H, et, al. Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules. 2011 Oct 11;16(10):8475-503.