152633-54-0

152633-54-0 structure

Name: Win-62005
Chemical Name: 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one
CAS Number: 152633-54-0
Molecular Formula: C₁₂H₁₀N₄O
Molecular Weight: 226.23400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2016-04-19 12:20:02
Modify Date: 2024-01-31 23:03:08
Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

Name	5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one
Synonyms	2H-Imidazo(4,5-b)pyridin-2-one,1,3-dihydro-5-methyl-6-(4-pyridinyl) 5-Methyl-6-(4-pyridinyl)-2H-imidazo(4,5-b)pyridin-2-one Win-62005

Description	Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease
Target	Ki: 25 nM (PDE III), 25 nM (PDE III)[1]
In Vitro	Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].
In Vivo	After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].
References	[1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.