1207258-55-6

1207258-55-6 structure

Name: NVS-CRF38
Chemical Name: nvs-crf38
CAS Number: 1207258-55-6
Molecular Formula: C₁₉H₂₁N₅O₂
Molecular Weight: 351.40200
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2018-02-21 08:46:19
Modify Date: 2024-01-11 10:23:56
NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.IC50 value: Target: CRF1 antagonist

Name	nvs-crf38
Synonyms	7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole 7-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-3-(4-methoxy-2-methyl-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazole

Description	NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.IC50 value: Target: CRF1 antagonist
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Others
References	[1]. Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3. [2]. Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24.