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174264-46-1

174264-46-1 structure
174264-46-1 structure
  • Name: 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
  • Chemical Name: [2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
  • CAS Number: 174264-46-1
  • Molecular Formula: C34H41NO4SSi
  • Molecular Weight: 587.84400
  • Catalog: Research Areas Others
  • Create Date: 2016-06-06 01:15:04
  • Modify Date: 2024-02-01 18:35:03
  • 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].
Name [2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-6-hydroxy-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
Synonyms 6-Hydroxy-4 inverted exclamation mark-tert-butyldimethylsylyl Raloxifene
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
Description 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].
Related Catalog
In Vitro The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide[1].
References

[1]. Dodge JA, et al. Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):97-106.
Density 1.15g/cm3
Boiling Point 706.195ºC at 760 mmHg
Molecular Formula C34H41NO4SSi
Molecular Weight 587.84400
Flash Point 380.893ºC
Exact Mass 587.25300
PSA 87.24000
LogP 8.69150
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.593
Precursor  2

DownStream  1


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