312631-87-1

312631-87-1 structure

Name: 3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione
Chemical Name: 10074-a4
CAS Number: 312631-87-1
Molecular Formula: C₁₈H₁₄Cl₂N₂O₃S
Molecular Weight: 409.28600
Catalog: Signaling Pathways Apoptosis c-Myc
Create Date: 2018-03-10 17:42:18
Modify Date: 2024-08-19 17:19:34
10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].

Name	10074-a4
Synonyms	3-[3-(3,6-dichlorocarbazol-9-yl)-2-hydroxypropyl]thiazolidine-2,4-dione 3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-1,3-thiazolidine-2,4-dione

Description	10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vitro	10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1]. 10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1]. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 25 μM, 50 μM Incubation Time: 24 hours Result: Arrested the cell cycle at the S-phase.
References	[1]. Chen Yu, et al. Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc. Sci Rep. 2016 Mar 2;6:22298. [2]. Fan Jin, et al. Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol. 2013;9(10):e1003249.