14432-09-8

14432-09-8 structure

Name: 1-Deazaadenosine
Chemical Name: 1-deazaadenosine
CAS Number: 14432-09-8
Molecular Formula: C₁₁H₁₄N₄O₄
Molecular Weight: 266.25300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Adenosine Deaminase
Create Date: 2018-02-15 03:58:03
Modify Date: 2024-01-03 16:16:20
1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].

Name	1-deazaadenosine
Synonyms	7-Amino-3-(β-D-ribofuranosyl)imidazo[4,5-b]pyridine 1-deaza-adenosine 1-(7-amino-imidazo[4,5-b]pyridin-3-yl)-β-D-1-deoxy-ribofuranose 1-Deazaadenosine

Description	1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase
In Vitro	1-Deazaadenosine shows good activity in vitro as inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth, with ID50 values ranging from 0.34 μM (KB) to 1.8 μM (P388)[2].
References	[1]. Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. [2]. Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30(9):1686-8.