1262780-97-1

1262780-97-1 structure

Name: Etelcalcetide
Chemical Name: Etelcalcetide
CAS Number: 1262780-97-1
Molecular Formula: C₃₈H₇₃N₂₁O₁₀S₂
Molecular Weight: 1048.25000
Catalog: Signaling Pathways GPCR/G Protein CaSR
Create Date: 2018-03-24 08:00:00
Modify Date: 2024-01-02 14:54:36
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

Name	Etelcalcetide
Synonyms	Velcalcetide AMG 416 KAI 4169 ONO 5163 Telcalcetide Parsabiv H-Cys(1)-OH.Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide

Description	Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CaSR
References	[1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.