78499-27-1

78499-27-1 structure

Name: Bermoprofen
Chemical Name: dl-2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid
CAS Number: 78499-27-1
Molecular Formula: C₁₈H₁₆O₄
Molecular Weight: 296.31700
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-02-15 19:01:56
Modify Date: 2024-01-09 19:03:16
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic and analgesic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits[1][2].

Name	dl-2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid
Synonyms	2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid Bermoprofen 2-(8-Methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)-propionic acid 2-(8-methyl-10,11-dihydro-11-oxodibenz<b,f>oxepin-2-yl)propionic acid bermoprofen 2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic acid 2-(8-Methyl-11-oxo-10,11-dihydro-dibenzo[b,f]oxepin-2-yl)-propionic acid

Description	Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic and analgesic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents[1].
In Vivo	Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits[2]. Animal Model: Male albino rabbits, 2.3-3 kg[2] Dosage: 0.04, 0.4, 0.1 mg/kg Administration: Oral; given 1 h after i.v. injection of LPS Result: Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg.
References	[1]. Mori M, et al. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80. [2]. Nakamura H, et al. AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits. J Pharm Pharmacol. 1984 Mar;36(3):182-6.