89128-99-4

89128-99-4 structure

Name: 5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine
Chemical Name: 5-N-methyl-N-TFA-aminomethyl-2-thiouridine
CAS Number: 89128-99-4
Molecular Formula: C₁₃H₁₆F₃N₃O₆S
Molecular Weight: 399.34
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-04-20 23:54:21
Modify Date: 2024-02-05 16:06:47
5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	5-N-methyl-N-TFA-aminomethyl-2-thiouridine
Synonyms	N-[1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl]-2,2,2-trifluoro-N-methyl-acetamide N-methyl-N-TFA-aminomethyl-2-thiouridine

Description	5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.