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307297-39-8

307297-39-8 structure
307297-39-8 structure
  • Name: Epithalon
  • Chemical Name: L-Alanyl-L-α-glutamyl-L-α-aspartylglycine
  • CAS Number: 307297-39-8
  • Molecular Formula: C14H22N4O9
  • Molecular Weight: 390.346
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Telomerase
  • Create Date: 2018-10-17 13:52:46
  • Modify Date: 2024-01-03 12:17:28
  • Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa[1].
Name L-Alanyl-L-α-glutamyl-L-α-aspartylglycine
Synonyms L-Alanyl-L-α-glutamyl-L-α-aspartylglycine
Glycine, L-alanyl-L-α-glutamyl-L-α-aspartyl-
L-Alanyl-L-α-glutamyl-L-α-asparagylglycin
Epithalon
Description Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa[1].
Related Catalog
In Vitro Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism[1].
In Vivo Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration[1].
References

[1]. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

[2]. Vanhee C, et al. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Test Anal. 2015 Mar;7(3):259-64.

[3]. Khavinson VKh, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
Density 1.5±0.1 g/cm3
Boiling Point 959.8±65.0 °C at 760 mmHg
Molecular Formula C14H22N4O9
Molecular Weight 390.346
Flash Point 534.3±34.3 °C
Exact Mass 390.138672
LogP -2.02
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.559
Hazard Codes Xi

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title: CAS No. 307297-39-8 | Chemsrc address: https://www.chemsrc.com/en/baike/1376135.html

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