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942398-84-7

942398-84-7 structure
942398-84-7 structure
  • Name: Amiselimod hydrochloride
  • Chemical Name: amiselimod hydrochloride
  • CAS Number: 942398-84-7
  • Molecular Formula: C19H31ClF3NO3
  • Molecular Weight: 413.902
  • Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
  • Create Date: 2018-08-06 06:24:22
  • Modify Date: 2024-01-05 18:19:39
  • Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.target: S1P1In vivo: After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1 , high selectivity for S1P5 , minimal agonist activity for S1P4 , no distinct agonist activity for S1P2 or S1P3 , and approximately 5-fold weaker GIRK activation than fingolimod-P. [1] Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions. [2]

Name amiselimod hydrochloride
Synonyms MT-1303
UNII-AY898D6RU1
AMISELIMOD HYDROCHLORIDE
2-Amino-2-{2-[4-(heptyloxy)-3-(trifluorométhyl)phényl]éthyl}-1,3-propanediol, chlorhydrate (1:1)
2-Amino-2-{2-[4-(heptyloxy)-3-(trifluormethyl)phenyl]ethyl}-1,3-propandiolhydrochlorid (1:1)
2-Amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}-1,3-propanediol hydrochloride (1:1)
1,3-Propanediol, 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
Amiselimod HCl
Description Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.target: S1P1In vivo: After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1 , high selectivity for S1P5 , minimal agonist activity for S1P4 , no distinct agonist activity for S1P2 or S1P3 , and approximately 5-fold weaker GIRK activation than fingolimod-P. [1] Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions. [2]
Related Catalog
References

[1]. Sugahara K et al. Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2016 Oct 7.

[2]. Kappos L et al. Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct;15(11):1148-59.

Molecular Formula C19H31ClF3NO3
Molecular Weight 413.902
Exact Mass 413.194458
Storage condition 2-8℃