139570-93-7
139570-93-7 structure
- Name: AEZS-108
- Chemical Name: an152
- CAS Number: 139570-93-7
- Molecular Formula: C91H117N19O26
- Molecular Weight: 1893.014
- Catalog: Research Areas Cancer
- Create Date: 2018-05-26 03:36:46
- Modify Date: 2024-01-12 12:25:51
-
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].
| Name | an152 |
|---|---|
| Synonyms |
an152
zoptarelin doxorubicin AEZS-108 aezs 108 |
| Description | Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1]. |
|---|---|
| Related Catalog | |
| Target |
Apoptosis, LHRH receptors[1] |
| In Vitro | Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1]. Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1]. Cell Proliferation Assay[1] Cell Line: U-87 MG Concentration: 100 nM Incubation Time: 48 h Result: Brought about an almost 70 % inhibition of tumor cell growth. Apoptosis Analysis[1] Cell Line: U-87 MG Concentration: 100 nM Incubation Time: 48 h Result: Increased almost 250 % apoptosis. Western Blot Analysis[1] Cell Line: U-87 MG Concentration: 100 nM Incubation Time: 24 h Result: Did not induce any down-regulation of LHRH-R. Inhibited the expression of the primordial, neuroectodermal stem cell marker, nestin. Up-regulated the tumor suppressor and pro-apoptotic p53. |
| In Vivo | Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1]. Animal Model: Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1] Dosage: 413 nM/20g Administration: i.v.; once weekly; for 6 weeks Result: Significantly inhibited tumor growth compared to the control. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C91H117N19O26 |
| Molecular Weight | 1893.014 |
| Exact Mass | 1891.841675 |
| LogP | 1.29 |
| Index of Refraction | 1.714 |