88217-10-1

88217-10-1 structure

Name: α-Conotoxin MI trifluoroacetate salt
Chemical Name: GRCCHPACGKNYSC-amide, cyclic (3→8),(4→14)-bis(disulfide)
CAS Number: 88217-10-1
Molecular Formula: C₅₈H₈₈N₂₂O₁₇S₄
Molecular Weight: 1493.72000
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-01-08 20:56:44
Modify Date: 2024-01-19 16:41:42
α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].

Name	GRCCHPACGKNYSC-amide, cyclic (3→8),(4→14)-bis(disulfide)
Synonyms	alpha-conotoxin MI α-Conotoxin MI trifluoroacetate salt

Description	α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	mAChR[2]; α1β1γδ nAChR[1]
In Vitro	α-Conotoxin M I interacts with the α-δ site of the AChR through four hydrophobic residues in its N- and C-terminal loops. Furthermore, the key side chains in α-Conotoxin M I localize in a hydrophobic cluster that interacts with hydrophobic and aromatic residues from both the a and d subunits[2].