160896-49-1

160896-49-1 structure

Name: Hosenkoside K
Chemical Name: Hosenkoside K
CAS Number: 160896-49-1
Molecular Formula: C₅₄H₉₂O₂₅
Molecular Weight: 1141.293
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-16 08:00:00
Modify Date: 2024-01-06 21:53:53
Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.

Name	Hosenkoside K
Synonyms	Glucopyranoside β-D-Glucopyranoside, (1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-glucopyranosyloxy)methyl]-6'-[(1S)-2-(β-D-glucopyranosyloxy)-1-methylethyl]octadecahydro-1-hydroxy-4a,4b,7,10a-tetram ethylspiro[chrysene-2(1H),3'(4'H)-[2H]pyran]-8-yl 2-O-β-D-glucopyranosyl- (1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-Glucopyranosyloxy)methyl]-6'-[(2S)-1-(β-D-glucopyranosyloxy)-2-propanyl]-1-hydroxy-4a,4b,7,10a-tetramethyloctadecahydro-1H,4'H-spiro[chrysene -2,3'-pyran]-8-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Description	Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Natural Products >> Saccharides and Glycosides
In Vivo	The mean peak concentrations of hosenkoside K in rats after oral administration of total saponins of Semen Impatientis is 511.11±234.07 ng/mL, occurring at times of 0.46 h. The terminal half-lives of hosenkoside A is 4.96±1.75 h[1].
Animal Admin	Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing.
References	[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).