1219802-12-6

1219802-12-6 structure

Name: Methyl Salicylate-d4
Chemical Name: Methyl salicylate
CAS Number: 1219802-12-6
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.147
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-01-08 10:40:26
Modify Date: 2024-01-06 20:21:14
Methyl Salicylate-d4 is the deuterium labeled Methyl Salicylate[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[2]. A systemic acquired resistance (SAR) signal in tobacco[3]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor[5].

Name	Methyl salicylate
Synonyms	2-Hydroxybenzoic acid methyl ester salicylic acid methyl ester Benzoic acid, 2-hydroxy-, methyl ester methyl 2-hydroxybenzoate methylsalicylate Wintergreen oil (generic) Methyl salicylate QR BVO1

Description	Methyl Salicylate-d4 is the deuterium labeled Methyl Salicylate[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[2]. A systemic acquired resistance (SAR) signal in tobacco[3]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor[5].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47(2):98-120. [3]. Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5318(5847):113-6. [4]. Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 200745 Suppl 1:S428-52. [5]. Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul171(14):3526-38.

Density	1.2±0.1 g/cm3
Boiling Point	222.0±0.0 °C at 760 mmHg
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	86.8±12.6 °C
Exact Mass	152.047348
LogP	2.23
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.547

1219802-12-6	154-26-7
226932-59-8	90045-28-6
119-36-8	8024-54-2
101231-54-3	7631-93-8
60770-00-5	61141-13-7
1158522-08-7	940364-43-2
134104-43-1	869075-73-0
131615-57-1	6906-52-1
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1