1391054-02-6
1391054-02-6 structure
- Name: Vigabatrin (Hydrochloride)
- Chemical Name: 4-Amino-5-hexenoic acid hydrochloride (1:1)
- CAS Number: 1391054-02-6
- Molecular Formula: C6H12ClNO2
- Molecular Weight: 165.618
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-06-21 14:37:02
- Modify Date: 2024-01-05 09:08:05
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Vigabatrin Hcl(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.IC50 value:Target: GABA transaminaseClinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 μg) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment.
| Name | 4-Amino-5-hexenoic acid hydrochloride (1:1) |
|---|---|
| Synonyms |
5-Hexenoic acid, 4-amino-, hydrochloride (1:1)
4-Amino-5-hexenoic acid hydrochloride (1:1) Vigabatrin (Hydrochloride) |
| Description | Vigabatrin Hcl(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.IC50 value:Target: GABA transaminaseClinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 μg) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment. |
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| Related Catalog | |
| References |
[4]. Vigabatrin |
| Molecular Formula | C6H12ClNO2 |
|---|---|
| Molecular Weight | 165.618 |
| Exact Mass | 165.055649 |
| Storage condition | 2-8℃ |